Twilight cast bids farewell at final premiere
















LOS ANGELES (Reuters) – Thousands of screaming fans lined the black carpet late on Monday for the final “Twilight” film premiere as the cast of “Breaking Dawn – Part 2″ bid farewell to the franchise and its loyal followers.


Robert Pattinson, Kristen Stewart, Taylor Lautner and other cast members greeted fans known as “Twi-hards,” many of whom had camped out for days in downtown Los Angeles to catch a glimpse of their favorite actors and see the film before it is released in theaters on Friday.













Breaking Dawn – Part 2 will see the love story of human Bella Swan (Stewart), vampire Edward Cullen (Pattinson) and werewolf Jacob Black (Lautner) come to a tantalizing end, when Bella and Edward are forced to protect their child from an ancient vampire coven.


Stewart, who was finally able to embrace her wild side by playing Bella as a vampire, hoped people would enjoy the ultimate transformation of her character in the film.


“Bella has worked pretty hard to get to the point where they can have it all, and it’s fun to be there. She’s always been human, but now that she’s not, you’re just in full blown vampire land and it feels funny in a great way,” Stewart told Reuters.


More than 2,200 fans from all over the world came to camp out on a concrete plaza in downtown Los Angeles last week, where Twilight movie studio Summit laid out activities and marathon screenings of the previous movies.


All of the film’s main actors spent time signing autographs and posing for photographs with the loyal fans who had camped out in chilly November weather over five days.


Pattinson, who plays vampire Edward Cullen, said he hoped the fans would like the franchise’s swan song.


“I hope they feel it kind of respects them, because I think in a lot of ways that’s what we were thinking when we were making it,” the actor said.


Lautner, who plays werewolf Jacob, said he’d be sad to say goodbye to the films and his character and hoped fans would be happy with the conclusion of the final film.


“I’m feeling fantastic, sad, emotional, there’s a lot of things going on inside of me right now but I’m just trying to soak up every moment because this means the world to me,” Lautner said.


The three lead stars were joined by fellow cast members including Nikki Reed, Ashley Greene, Kellan Lutz, Jackson Rathbone, Michael Sheen and Dakota Fanning, as well as director Bill Condon and author Stephenie Meyer, whose Twilight novels kicked off the franchise and phenomenon.


Meyer said she would miss watching the three lead cast members evolve as actors and characters in the films.


“It’s really been great to watch them grow up, particularly Kristen because her character gets to evolve so much in this film, and to watch her be all powerful and really get to where the character was always meant to go, to be the fiercest of the fierce, was really rewarding for me,” the author said.


(Reporting By Piya Sinha-Roy, editing by Paul Casciato)


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Report: FDA wanted to close Mass pharmacy in 2003
















WASHINGTON (AP) — Nearly a decade ago, federal health inspectors wanted to shut down the pharmacy linked to a recent deadly meningitis outbreak until it cleaned up its operations, according to congressional investigators.


About 440 people have been sickened by contaminated steroid shots distributed by New England Compounding Center, and more than 32 deaths have been reported since the outbreak began in September, according to the Centers for Disease Control and Prevention. That has put the Framingham, Mass.-based pharmacy at the center of congressional scrutiny and calls for greater regulation of compounding pharmacies, which make individualized medications for patients and have long operated in a legal gray area between state and federal laws.













The House Energy and Commerce Committee released a detailed history of NECC‘s regulatory troubles on Monday, ahead of a meeting Wednesday meeting to examine how the outbreak could have been prevented. The 25-page report summarizes and quotes from FDA and state inspection memos, though the committee declined to release the original documents.


The report shows that after several problematic incidents, Food and Drug Administration officials in 2003 suggested that the compounding pharmacy be “prohibited from manufacturing” until it improved its operations. But FDA regulators deferred to their counterparts in Massachusetts, who ultimately reached an agreement with the pharmacy to settle concerns about the quality of its prescription injections.


The congressional report also shows that in 2003 the FDA considered the company a pharmacy. That’s significant because in recent weeks public health officials have charged that NECC was operating more as a manufacturer than a pharmacy, shipping thousands of doses of drugs to all 50 states instead of small batches of drugs to individual patients. Manufacturers are regulated by the FDA and are subject to stricter quality standards than pharmacies.


The report offers the most detailed account yet of the numerous regulatory complaints against the pharmacy, which nearly date back to its founding in 1998. Less than a year later, the company was cited by the state pharmacy board for providing doctors with blank prescription pads with NECC’s information. Such promotional items are illegal in Massachusetts and the pharmacy’s owner and director, Barry Cadden, received an informal reprimand, according to documents summarized by the committee.


Cadden was subject to several other complaints involving unprofessional conduct in coming years, but first came to the FDA’s attention in 2002. Here are some key events from the report highlighting the company’s early troubles with state and federal authorities:


__ In March of 2002 the FDA began investigating reports that five patients had become dizzy and short of breath after receiving NECC’s compounded betamethasone repository injection, a steroid used to treat joint pain and arthritis that’s different from the one linked to the current meningitis outbreak.


FDA inspectors visited NECC on April 9 and said Cadden was initially cooperative in turning over records about production of the drug. But during a second day of inspections, Cadden told officials “that he was no longer willing to provide us with any additional records,” according to an FDA report cited by congressional investigators. The inspectors ultimately issued a report citing NECC for poor sterility and record-keeping practices but said that “this FDA investigation could not proceed to any definitive resolution,” because of “problems/barriers that were encountered throughout the inspection.”


__ In October of 2002, the FDA received new reports that two patients at a Rochester, N.Y., hospital came down with symptoms of bacterial meningitis after receiving a different NECC injection. The steroid, methylprednisolone acetate, is the same injectable linked to the current outbreak and is typically is used to treat back pain. Both patients were treated with antibiotics and eventually recovered, according to FDA documents cited by the committee.


When officials from the FDA and Massachusetts Board of Pharmacy visited NECC later in the month, Cadden said vials of the steroid returned by the hospital had tested negative for bacterial contamination. But when FDA scientists tested samples of the drug collected in New York they found bacterial contamination in four out of 14 vials sampled. It is not entirely clear whether FDA tested the same lot shipped to the Rochester hospital.


__ At a February 2003 meeting between state and federal officials, FDA staff emphasized “the potential for serious public consequences if NECC’s compounding practices, in particular those relating to sterile products, are not improved.” The agency issued a list of problems uncovered in its inspection to NECC, including a failure to verify if sterile drugs met safety standards.


But the agency decided to let Massachusetts officials take the lead in regulating the company, since pharmacies are typically regulated at the state level. It was decided that “the state would be in a better position to gain compliance or take regulatory action against NECC as necessary,” according to a summary of the meeting quoted by investigators.


The FDA recommended the state subject NECC to a consent agreement, which would require the company to pass certain quality tests to continue operating. But congressional investigators say Massachusetts Board of Pharmacy did not take any action until “well over a year later.”


__ In October 2004, the board sent a proposed consent agreement to Cadden, which would have included a formal reprimand and a three-year probationary period for the company’s registration. The case ended without disciplinary action in 2006, when NECC agreed to a less severe consent decree with the state.


Massachusetts officials indicated Tuesday they are still investigating why NECC escaped the more severe penalty.


“I will not be satisfied until we know the full story behind this decision,” the state’s interim health commissioner Lauren Smith said in a transcript of her prepared testimony released a day ahead of delivery. Smith is one of several witnesses scheduled to testify Wednesday, including FDA Commissioner Margaret Hamburg.


The committee will also hear from the widow of 78-year-old Eddie C. Lovelace, a longtime circuit court judge in southern Kentucky. Autopsy results confirmed Lovelace received fungus-contaminated steroid injections that led to his death Sept. 17.


Joyce Lovelace will urge lawmakers to work together on legislation to stop future outbreaks caused by compounded drugs, according to a draft of her testimony.


“We now know that New England Compounding Pharmacy, Inc. killed Eddie. I have lost my soulmate and life’s partner with whom I worked side by side, day after day for more than fifty years,” Lovelace states.


Barry Cadden is also scheduled to appear at the hearing, after lawmakers issued a subpoena to compel him to attend.


The NECC has been closed since early last month, and Massachusetts officials have taken steps to permanently revoke its license. The pharmacy has recalled all the products it makes, including 17,700 single-dose vials of a steroid that tested positive for the fungus tied to the outbreak.


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How Often Do People Have Sex at the Office?
















As someone who reads people’s sex diaries professionally—for my books and website I collect thousands of them—I am here to report that former CIA Director David Petraeus is really just a talented guy who, considering his marital and work history, is a typical American male.


Petraeus has been married for 38 years. Very few human beings sleep with just one person in a 38-year period. Most people simply aren’t married that long. According to the Census, the majority of marriages end long before the 38th anniversary mark (the average divorce occurs eight years after the wedding), and of the marriages that stay intact for 38 years, approximately half involve at least one other sexual partner.













Various news outlets reported that Petraeus had sex under his desk at CIA headquarters. This makes his case a rare one. Although the workplace is the most common place to meet a new partner, few people actually have sex at the office—in the 3,500 diaries I’ve read, a grand total of 11 office affairs actually took place within the workplace walls. Workaholics logging long hours, particularly those working 12- to 18-hour days, account for seven of those 11. (Oh, and regarding the issue of on the desk vs. under the desk, I’ve discovered that people who prefer steadiness and balance—and the kinds of sexual positions given names such as “missionary,” for instance—opt for the floor. The desk is the domain of more acrobatic love-makers.)


Offices are no longer the great bastions of sex that they were in the Mad Men era, when doors were thick and carpeting thicker. The age of wide open “co-working environments,” glass walls, and security cameras has made the office a difficult place to find privacy. (Unless, of course, your office in a mid-20th-century government building is possibly camera-free and fully secure because you’re the head of U.S. intelligence—and perhaps your boss will never notice because he’s the president of the U.S. during an election year. Just saying.)


Regardless, privacy aside, there’s one thing I find to be an absolute certainty: If you communicated evidence of your lovemaking by e-mail or text message—like Petraeus apparently did—my research shows that you will likely be found out. All cheating affairs I encountered were discovered because of a digital paper trail. Remember, people: Don’t put it in writing.


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Canada seen needing to spell out rules for natural gas projects
















CALGARY, Alberta (Reuters) – The fate of a handful of liquefied natural gas projects planned for Canada’s Pacific coast may depend on the Canadian government‘s willingness to spell out rules for foreign investment in the country’s energy sector, according to a study released on Thursday.


Apache Corp, Royal Dutch Shell Plc, Petronas, BG Group Plc and others are in the planning stages for LNG projects that would take gas from the rich shale fields of northeastern British Columbia and ship it to Asian buyers.













But the federal government’s decision last month to stall the C$ 5.2 billion ($ 5.2 billion) bid by Malaysia’s state-owned Petronas C$ 5.2 billion for Canada‘s Progress Energy Resources Corp could lessen the appetite of Asian buyers for Canadian LNG, energy consultants Wood Mackenzie said.


“Some potential off-takers of Canadian LNG like the idea … because it’s perceived as having low political risk, and another reason is because they see the potential for investment opportunities,” said Noel Tomnay, head of global gas at the consultancy.


“If there are going to be restrictions on how they access those opportunities, if acquisitions are closed to them, then clearly that would restrict the attractiveness of those opportunities. If would-be Asian investors thought that corporate acquisitions were an avenue that was not open to them then Canadian LNG would become less attractive.”


The Canadian government is looking to come up with rules governing corporate acquisitions by state-owned companies and has pushed off a decision on the Petronas bid as it considers whether to approve the $ 15.1 billion offer for Nexen Inc from China’s CNOOC Ltd.


Exporting LNG to Asia is seen as a way to boost returns for natural-gas producers tapping the Montney, Horn River and Liard Basin shale regions of northeastern British Columbia.


Though Wood Mackenzie estimates the fields contain as much as 280 trillion cubic feet of gas, they are far from Canada’s traditional U.S. export market, while growing supplies from American shale regions have cut into Canadian shipments.


Because the region lacks infrastructure, developing the resource will be expensive, requiring new pipelines and multibillion-dollar liquefaction.


Still Wood Mackenzie estimates that the cost of delivery into Asian markets for Canadian LNG would be in the range of $ 10 million to $ 12 per million British thermal units, similar to competing projects in the United States and East Africa.


($ 1 = $ 1.00 Canadian)


(Reporting by Scott Haggett; Editing by Leslie Adler)


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Political Polling After the End of the Phone
















With over a third of U.S. households forgoing the land-line and people using their phones less and less for talking, the phone call is no longer the best way for pollsters to reach the people they need to speak with. With that changing trend, this election season polling places like Gallup worked cell-phone calls into its repertoire to get a better reflection of society, Gallup spokesperson Frank Newport told Wired‘s Mat Honan. And, logically, as more people replace landlines for cell phones, polling would increasingly throw cell-phones into the mix. But, it doesn’t look like that’s really the next frontier in polling. For one, it’s expensive. A 1996 Federal regulation requires that calls to cell phones be hand-dialed, rather than computer generated, which costs more money because employing people (rather than machines) takes dollars, notes Bits Blog’s Quentin Hardy. Plus, because of caller-ID, guilting cell phone users into taking a poll proves harder than haranguing an unsuspecting land-line answerer. (Of course, many land-line owners have caller-ID, too.) So, if the annoying, always disruptive at the worst time, pollster phone call is on the outs, then what does the future of political polling hold?


RELATED: More Than Half of America Likes Obama Again













Survey Monkey


RELATED: Poll: Rick Perry Bests Mitt Romney Among Tea Partiers


For real. The amateur-looking website conducted a series of polls throughout this election period, at times with better accuracy than the over-the-phone guys. In an explanatory post on the site, the company explains it had 96 percent accuracy with its methods. Over 60,000 people took one of the site’s surveys the day before election day alone, SurveyMonkey’s vice president, Philip Garland, told Hardy. 


RELATED: Poll: GOP Race Now Between Newt, Sarah, Mitt and Everyone Else


Though some have questioned the accuracy of the online poll because of its newness to the field. Nate Silver, whose words on all things polling we should now consider law, confirmed that many of the most accurate polling came from online surveys. “When people are asked questions by a person, they feel like they should make a choice,” Garland added. People are more candid on the Internet, which is not at all surprising. 


RELATED: Rick Perry Is Still Leading Despite Some Bad Debates


Text Messages


RELATED: Less Than Half of America Knows What GOP Stands For


Though a new survey says that text messaging is on the decline, Gallup is already experimenting with it as a polling technique in Central and South America, notes Honan. Though it doesn’t sound that different than screening a phone call, text messages are a lot less invasive and they don’t require an answer right away. Also, increasingly, it is how people do much of their communicating. 


Emails, Unfortunately


Though that sounds logical since so many Americans are accessible by email, it turns out it is too hard to get a good sample using email, since many people have multiple email addresses, and it’s hard to account for that difference. Also, isn’t it just so easy to click delete without opening? However, that hasn’t stopped certain organizations from using it, as Bloomberg Businessweek‘s Peter Coy explains. Some firms use email lists that aren’t representative of the general population, he notes. 


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U2′s Bono to urge U.S. politicians not to cut aid programs
















WASHINGTON (Reuters) – Irish rocker and anti-poverty campaigner Bono will appeal to Democrats and Republicans during a visit to Washington this week to spare U.S. development assistance programs from cuts as Congress tries to avert the looming “fiscal cliff” of tax hikes and spending reductions early next year.


The U2 lead singer’s visit comes as the Obama administration and congressional leaders try to forge a deal in coming weeks to avoid the economy hitting the “fiscal cliff” – tax increases and spending cuts worth $ 600 billion starting in January if Congress does not act.













Analysts say the absence of a deal could shock the United States, the world’s biggest economy, back into recession.


Kathy McKiernan, spokeswoman for the ONE Campaign, said Bono will hold talks with congressional lawmakers and senior Obama administration officials during the November 12-14 visit.


During meetings he will stress the effectiveness of U.S. foreign assistance programs and the need to preserve them to avoid putting at risk progress made in fighting HIV/AIDS, tuberculosis and malaria, she said.


Bono, a long-time advocate for the poor, will argue that U.S. government-funded schemes that support life-saving treatments for HIV/AIDS sufferers, nutrition programs for malnourished children, and emergency food aid make up just 1 percent of the U.S. government budget but are helping to save tens of millions of lives in impoverished nations.


The One Campaign would not elaborate which lawmakers and senior Obama administration officials Bono will meet.


On Monday, Bono will discuss the power of social movements with students at Georgetown University. He will also meet new World Bank President Jim Yong Kim for a web cast discussion on Wednesday on the challenges of eradicating poverty.


(Editing by W Simon)


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FDA find bugs, flying bird, at affiliate of meningitis pharmacy
















(Reuters) – U.S. inspectors found bugs, a flying bird and other unsterile conditions at Ameridose LLC, an affiliate of the New England Compounding Center at the heart of the deadly meningitis outbreak.


A report from the U.S. Food and Drug Administration detailed a list of failures at Ameridose that also included a failure to appropriately classify patient complaints and the use of “vague, canned language” when describing adverse reactions to its drugs.













The company said it is in the process of preparing a full response to the FDA.


(Reporting By Toni Clarke; Editing by Alden Bentley)


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Greek lawmakers back fresh cuts

















Greek lawmakers have approved a 2013 budget involving fresh spending cuts, despite mass public street protests.













The budget was backed in by 167 votes to 128. The bill was a pre-condition for Athens to be granted a 31.5bn euro (£25bn; $ 40bn) EU/IMF loan necessary to stave off bankruptcy.


Another austerity package of tax rises and pension cuts was passed last week.


Ahead of the vote, more than 10,000 protesters rallied outside the parliament in the capital, Athens.


Prime Minister Antonis Samaras earlier warned that without the new loan, Greece would start running out of money on Friday.


Eurozone finance ministers are due to meet just hours after the vote in Athens, and Mr Samaras is now expected to travel to Brussels for a series of meetings.


The problem that he faces is that it could take some weeks before the EU backs the new instalment, BBC Athens correspondent Mark Lowen reports. The measure will have to be approved first by some parliaments, including Germany’s.


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BBC must reform or die, says Trust chairman
















LONDON (Reuters) – The BBC could be doomed unless it makes radical changes, the head of its governing trust said on Sunday, after its director general quit to take the blame for the airing of false child sex abuse allegations against a former politician.


Chris Patten, chairman of the BBC Trust, said confidence had to be restored if the publicly funded corporation was to withstand pressure from rivals, especially Rupert Murdoch‘s media empire, which would try to take advantage of the turmoil.













“If you’re saying, ‘Does the BBC need a thorough structural radical overhaul?’, then absolutely it does, and that is what we will have to do,” Patten, a one-time senior figure in Prime Minister David Cameron‘s Conservative Party and the last British governor of Hong Kong, told BBC television.


“The basis for the BBC’s position in this country is the trust that people have in it,” Patten said. “If the BBC loses that, it’s over.”


George Entwistle resigned as director general on Saturday, just two months into the job, to take responsibility for the child sex allegation on the flagship news programme Newsnight.


The witness in the report, who says he suffered sexual abuse at a care home in the late 1970s, said on Friday he had misidentified the politician, Alistair McAlpine. Newsnight admitted it had not shown the witness a picture of McAlpine, or approached McAlpine for comment before going to air.


Already under pressure after revelations that a long-time star presenter, the late Jimmy Savile, was a paedophile, Entwistle conceded on the BBC morning news that he had not known – or asked – who the alleged abuser was until the name appeared in social media.


The BBC, celebrating its 90th anniversary, is affectionately known in Britain as “Auntie”, and respected around much of the world.


But with 22,000 staff working at eight national TV channels, 50 radio stations and an extensive Internet operation, critics say it is hampered by a complex and overly bureaucratic and hierarchical management structure.


THOMPSON’S LEGACY


Journalists said this had become worse under Entwistle’s predecessor Mark Thompson, who took over in the wake of the last major crisis to hit the corporation and is set to become chief executive of the New York Times Co on Monday.


In that instance, both director general and chairman were forced out after the BBC was castigated by a public inquiry over a report alleging government impropriety in the fevered build up to war in Iraq, leading to major organisational changes.


One of the BBC’s most prominent figures, Newsnight presenter Jeremy Paxman, said since the Iraq report furore, management had become bloated while cash had been cut from programme budgets.


“He (Entwistle) has been brought low by cowards and incompetents,” Paxman said in a statement, echoing a widely-held view that Entwistle was a good man who had been let down by his senior staff.


Prime Minister Cameron appeared ready to give the BBC the benefit of the doubt, believing that “one of the great institutions of this country” could reform and deal with its failings, according to sources in his office.


Patten, who must find a new director general to sort out the mess, agreed that management structures had proved inadequate.


“Apparently decisions about the programme went up through every damned layer of BBC management, bureaucracy, legal checks – and still emerged,” he said.


“One of the jokes I made, and actually it wasn’t all that funny, when I came to the BBC … was that there were more senior leaders in the BBC then there were in the Chinese Communist Party.”


Patten ruled out resigning himself but other senior jobs are expected to be on the line, while BBC supporters fear investigative journalism will be scaled back. He said he expected to name Entwistle’s successor in weeks, not months.


Among the immediate challenges are threats of litigation.


McAlpine, a close ally of former prime minister Margaret Thatcher, has indicated he will sue for damages.


Claims for compensation are also likely from victims who say Savile, one of the most recognisable personalities on British television in the 1960s, 70s and 80s, sexually abused them as children, sometimes on BBC premises.


INQUIRIES


Two inquiries are already under way, looking at failures at Newsnight and allegations relating to Savile, both of which could make uncomfortable reading for senior figures.


Police have also launched a major inquiry into Savile’s crimes and victims’ allegations of a high-profile paedophile ring. Detectives said they had arrested their third suspect on Sunday, a man in his 70s from Cambridgeshire in central England.


Funded by an annual licence fee levied on all TV viewers, the BBC has long been resented by its commercial rivals, who argue it has an unfair advantage and distorts the market.


Murdoch’s Sun tabloid gleefully reported Entwistle’s departure with the headline “Bye Bye Chump” and Patten said News Corp and others would put the boot in, happy to deflect attention after a phone-hacking scandal put the newspaper industry under intense and painful scrutiny.


He said that “one or two newspapers, Mr. Murdoch’s papers” would love to see the BBC lose its national status, “but I think the great British public doesn’t want to see that happen”.


Murdoch himself was watching from afar.


“BBC getting into deeper mess. After Savile scandal, now prominent news program falsely names senior pol as paedophile,” he wrote on his Twitter website on Saturday.


It is not just the BBC and the likes of Entwistle and Patten who are in the spotlight.


Thompson, whom Entwistle succeeded in mid-September, has also faced questions from staff at the New York Times over whether he is still the right person to take one of the biggest jobs in American newspaper publishing.


Britain’s Murdoch-owned Sunday Times queried how Thompson could have been unaware of claims about Savile during his tenure at the BBC as he had told British lawmakers, saying his lawyers had written to the paper addressing the allegations in early September, while he was still director general.


(Editing by Kevin Liffey and Sophie Hares)


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Malaysian charged with Facebook insult of sultan; sister says he’ll file police complaint
















KUALA LUMPUR, Malaysia – The sister of a Malaysian man who has been charged with insulting a state sultan on Facebook says he is innocent and plans to lodge a complaint over his detention.


Anisa Abdul Jalil, sister of Ahmad Abdul Jalil, says her brother was charged Thursday with making offensive postings on Facebook last month.













She says the charges are ridiculous because there is no evidence linking Ahmad to the posts in question, which were made by someone using the name “Zul Yahaya.”


Ahmad was freed on bail Thursday after six days of detention. Anisa says he will file a complaint with police for unlawful detention and intimidation.


Nine Malaysian states have sultans and other royal figures. Though their roles are largely ceremonial, acts provoking hatred against them are considered seditious.


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